Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection

  title={Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Na{\"i}ve Subjects with Progressive HIV-1 Subtype C Infection},
  author={Martin Roelsgaard Jakobsen and Kieran Y Cashin and Michael Roche and Jasminka Sterjovski and Anne Ellett and Katharina Borm and Jacqueline K. Flynn and Christian Erikstrup and Maelenn Gouillou and Lachlan R. Gray and Nitin K Saksena and Bin Wang and Damian Purcell and Per Kallestrup and Rutendo B. L. Zinyama-Gutsire and Exnevia Gomo and Henrik Ullum and Lars J\orgen \Ostergaard and Benhur Lee and Paul A. Ramsland and Melissa J. Churchill and Paul R. Gorry},
  booktitle={PloS one},
HIV-1 subtype C (C-HIV) is responsible for most HIV-1 cases worldwide. Although the pathogenesis of C-HIV is thought to predominantly involve CCR5-restricted (R5) strains, we do not have a firm understanding of how frequently CXCR4-using (X4 and R5X4) variants emerge in subjects with progressive C-HIV infection. Nor do we completely understand the molecular determinants of coreceptor switching by C-HIV variants. Here, we characterized a panel of HIV-1 envelope glycoproteins (Envs) (n = 300… CONTINUE READING
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Establishment of a new system for determination of coreceptor usages of HIV based on the human glioma NP-2 cell line.

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