Longitudinal (1)H relaxation optimization in TROSY NMR spectroscopy.

  title={Longitudinal (1)H relaxation optimization in TROSY NMR spectroscopy.},
  author={Konstantin Pervushin and Beat V{\"o}geli and Alexander Eletsky},
  journal={Journal of the American Chemical Society},
  volume={124 43},
A general method to enhance the sensitivity of the multidimensional NMR experiments performed at high-polarizing magnetic field via the significant reduction of the longitudinal proton relaxation times is described. The method is based on the use of two vast pools of "thermal bath" 1H spins residing on hydrogens covalently attached to carbon and oxygen atoms in 13C,15N labeled and fully protonated or fractionally deuterated proteins to uniformly enhance longitudinal relaxation of the 1HN spins… CONTINUE READING

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