Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.

@article{Bitterman2003LongevityRI,
  title={Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.},
  author={Kevin J. Bitterman and Oliver Medvedik and David A Sinclair},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2003},
  volume={67 3},
  pages={376-99, table of contents}
}
When it was first proposed that the budding yeast Saccharomyces cerevisiae might serve as a model for human aging in 1959, the suggestion was met with considerable skepticism. Although yeast had proved a valuable model for understanding basic cellular processes in humans, it was difficult to accept that such a simple unicellular organism could provide information about human aging, one of the most complex of biological phenomena. While it is true that causes of aging are likely to be… CONTINUE READING

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