Longevity of lobsters is linked to ubiquitous telomerase expression

  title={Longevity of lobsters is linked to ubiquitous telomerase expression},
  author={Wolfram Klapper and Karen K{\"u}hne and Kumud Singh and Klaus Heidorn and Reza M. Parwaresch and Guido Krupp},
  journal={FEBS Letters},

Developmental pattern of telomerase expression in the sand scallop, Euvola ziczac

The first report of telomerase expression in a bivalve species, the sand scallop, Euvola ziczac, is presented and suggests that these scallops do not use telomerases repression as a mechanism to suppress the formation of neoplasm.

Telomerase Activity and Telomere Length in Daphnia

The results indicate that there is no age-dependent decline in telomere length, telomerase activity, or processivity in short-lived D. pulex, and indicate that mechanisms other than telomeres shortening may be responsible for the strikingly short life span of D. pulicaria.

Impaired telomerase activity hinders proliferation and in vitro transformation of Penaeus monodon lymphoid cells

Undetectable telomerase activity in lymphoid cell culture supports the hypothesis that the inadequate telomersase activity or gene expression may be a reason that prevents neoplastic transformation and spontaneous immortalization of the cells in vitro.

Upregulation of Telomerase Function During Tissue Regeneration

The expression of telomerase in aquatic animals is likely not related to longevity but to their ability to regenerate injured tissue, indicating the importance for maintaining telomere length and integrity during tissue regeneration.

Expression of Telomerase Reverse Transcriptase in Adult Goldfish Retina

The results suggest the role of telomerase in vertebrate central nervous system (CNS) other than telomere maintenance, such as regulation of cell cycle progression and maintenance of retinal cell phenotypes.

The Role of Telomere-Telomerase System in Age-Related Fitness Decline , a Tameable Process

The prospect that senescence will be tamed in the not too distant future, in particular by control of, or more audaciously, by a modification of, the genetic determinants of the telomere-telomerase system is discussed.

Distribution of TTAGG-specific telomerase activity in insects

It is shown that telomerase is upregulated in young instars and gradually declines during development, and in adults, it is most active in testes and ovaries, which seems to be associated with cell proliferation and organismal development.

Detection of Telomerase Activity in Tissues and Primary Cultured Lymphoid Cells of Penaeus japonicus

Primary cultured lymphoid cells of Penaeus japonicus possess one of the factors necessary for cell line establishment, and the activity of this telomerase was decreased but still readily detectable in 100 ng of protein extract from lymphoid tissue.

Telomerase, immortality and cancer.




Characterization and developmental patterns of telomerase expression in plants.

Telomerase activation appears to be a conserved mechanism involved in conferring long-term proliferation capacity in plants, and might reflect the capacity to form telomeres on broken chromosomes in vivo.

Telomerase activity in human germline and embryonic tissues and cells.

Elucidation of the regulatory pathways involved in the repression of telomerase activity during development may lead to the ability to manipulate telomere levels and explore the consequences both for cellular aging and for the survival of cancer cells.

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

  • K. ProwseC. Greider
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1995
It is suggested that there is tissue-specific regulation of mouse telomerase during development and aging in vivo, and most mouse tissues had active telomerases, compared to human tissues, which may reflect the ease of immortalization of primary mouse cells relative to human cells in culture.

Lack of cell cycle regulation of telomerase activity in human cells.

Although it is not necessary for all cell types to regulate telomerase in the same way, it is concluded that in the immortal cultured cell lines examined, extracted telomersase activity does not change significantly during progression through the stages of the cell cycle.

Telomere elongation in immortal human cells without detectable telomerase activity.

It is suggested that the presence of lengthened or stabilized telomeres is necessary for immortalization, and that this may be achieved either by the reactivation of telomerase or by a novel and as yet unidentified mechanism.

Telomeres shorten during ageing of human fibroblasts

The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.