Longevity is impacted by growth hormone action during early postnatal period

Abstract

Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal littermate control mice in a genotype and sex-specific manner. Studies in a separate cohort of Ames dwarf mice show that… (More)
DOI: 10.7554/eLife.24059

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