Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

@article{Rudolph1999LongevitySR,
  title={Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice},
  author={K. Rudolph and S. Chang and H. Lee and M. Blasco and G. Gottlieb and C. Greider and R. DePinho},
  journal={Cell},
  year={1999},
  volume={96},
  pages={701-712}
}
Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the effects associated with critical telomere shortening at the organismal level. We studied a variety of physiological processes in an aging cohort of mTR-/- mice. Loss of telomere function did not elicit a full spectrum of classical pathophysiological symptoms of aging. However… Expand
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