Longer therapy, iatrogenic amenorrhea, and survival in early breast cancer.

  title={Longer therapy, iatrogenic amenorrhea, and survival in early breast cancer.},
  author={Sandra M Swain and J Jeong and Charles Edward Geyer and J. P. Costantino and Eduardo R. Pajon and Louis Fehrenbacher and James Norman Atkins and Jonathan A. Polikoff and Victor G. Vogel and John K. Erban and Priya Rastogi and Robert B. Livingston and Edith A. Perez and Eleftherios P Mamounas and Stephanie R. Land and Patricia A. Ganz and Norman Wolmark},
  journal={The New England journal of medicine},
  volume={362 22},
BACKGROUND Chemotherapy regimens that combine anthracyclines and taxanes result in improved disease-free and overall survival among women with operable lymph-node-positive breast cancer. The effectiveness of concurrent versus sequential regimens is not known. METHODS We randomly assigned 5351 patients with operable, node-positive, early-stage breast cancer to receive four cycles of doxorubicin and cyclophosphamide followed by four cycles of docetaxel (sequential ACT); four cycles of… CONTINUE READING
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Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15 - year survival : an overview of the randomized trials

  • JM Nabholtz, C Falkson, D Campos
  • Lancet
  • 2005

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