Longer Telomere Length in Peripheral White Blood Cells Is Associated with Risk of Lung Cancer and the rs2736100 (CLPTM1L-TERT) Polymorphism in a Prospective Cohort Study among Women in China

@inproceedings{Lan2013LongerTL,
  title={Longer Telomere Length in Peripheral White Blood Cells Is Associated with Risk of Lung Cancer and the rs2736100 (CLPTM1L-TERT) Polymorphism in a Prospective Cohort Study among Women in China},
  author={Qing Lan and Richard M. Cawthon and Yu-tang Gao and Wei Hu and Howard Dean Hosgood and Francesco Barone-Adesi and Bu-tian Ji and Bryan A Bassig and Wong-Ho Chow and Xiaoou Shu and Qiuyin Cai and Yongbin Xiang and Sonja I. Berndt and Christopher F Kim and Stephen K Chanock and Wei Zheng and Nathaniel Rothman},
  booktitle={PloS one},
  year={2013}
}
A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk of adenocarcinoma of the lung. The telomerase gene TERT is a reverse transcriptase that is critical for telomere replication and stabilization by controlling telomere length. We previously found that longer telomere length measured in peripheral white blood cell… CONTINUE READING
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