Long-term valproate treatment induces changes in ovarian morphology and serum sex steroid hormone levels in female Wistar rats

@article{Taubll1999LongtermVT,
  title={Long-term valproate treatment induces changes in ovarian morphology and serum sex steroid hormone levels in female Wistar rats},
  author={Erik Taub\oll and Jouko Isoj{\"a}rvi and Hanne F. Harbo and Arto J. Pakarinen and Leif Gjerstad},
  journal={Seizure},
  year={1999},
  volume={8},
  pages={490-493}
}
Long-term valproate treatment is associated with polycystic ovaries and endocrine disorders in women with epilepsy. The mechanisms responsible for these effects are unknown, but both the epilepsy itself and the drug per se may be of importance. The aim of this study was to investigate possible effects of the drug on gonadal structure and function in animals with no epileptic disorders. Three groups, each of 15 female Wistar rats, were fed perorally with a valproate mixture (50 mg / kg or 200 mg… CONTINUE READING
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