Long-term use of temozolomide: could you use temozolomide safely for life in gliomas?

@article{Khasraw2009LongtermUO,
  title={Long-term use of temozolomide: could you use temozolomide safely for life in gliomas?},
  author={Mustafa Khasraw and David Bell and Helen Wheeler},
  journal={Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year={2009},
  volume={16 6},
  pages={854-5}
}
Temozolomide (TMZ) is an alkylating agent used in the management of gliomas. Although TMZ is generally safe and acute toxicity is well documented, there are limited data on long-term toxicities. We present three patients with glioma; all patients started on TMZ after having progressed following primary treatment. These patients have continued TMZ for 5 years, 7 years and 8 years respectively. So far they have had no serious side effects. We discuss these patients while raising the question of… CONTINUE READING

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