Long-term use of sildenafil in the therapeutic management of heart failure.

@article{Guazzi2007LongtermUO,
  title={Long-term use of sildenafil in the therapeutic management of heart failure.},
  author={Marco Guazzi and Michele Samaja and Ross Arena and Marco Vicenzi and Maurizio D. Guazzi},
  journal={Journal of the American College of Cardiology},
  year={2007},
  volume={50 22},
  pages={2136-44}
}
OBJECTIVES This study sought to test the functional exercise capacity and endothelial function in a cohort of chronic heart failure (CHF) patients treated with chronic type 5 phosphodiesterase (PDE5) inhibitor. BACKGROUND In CHF, endothelial dysfunction is involved in muscle underperfusion, ergoreflex oversignaling, and exercise ventilation inefficiency. Inhibition of PDE5 by improving endothelial dysfunction might be beneficial. METHODS Stable CHF patients were randomly assigned to placebo… CONTINUE READING

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