Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans

  title={Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans},
  author={Jos{\'e} Carlos Bouso and Fernanda Palhano-Fontes and Antoni Rodr{\'i}guez-Fornells and Sidarta Ribeiro and Jordi R. Riba},
  journal={European Neuropsychopharmacology},
Psychedelic agents have a long history of use by humans for their capacity to induce profound modifications in perception, emotion and cognitive processes. Despite increasing knowledge of the neural mechanisms involved in the acute effects of these drugs, the impact of sustained psychedelic use on the human brain remains largely unknown. Molecular pharmacology studies have shown that psychedelic 5-hydroxytryptamine (5HT)2A agonists stimulate neurotrophic and transcription factors associated… CONTINUE READING


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