Long-term use of bisphosphonates in osteoporosis.

  title={Long-term use of bisphosphonates in osteoporosis.},
  author={Nelson B. Watts and Dima L Diab},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={95 4},
CONTEXT Bisphosphonates have been widely used in the treatment of osteoporosis. Uncommon side effects have emerged in postapproval use. Because bisphosphonates accumulate in bone and are released for months or years after treatment is stopped, it is reasonable to consider the clinical question of how long to treat. OBJECTIVE In this personal perspective, we review the pharmacology and mechanism of action of bisphosphonates and the clinical studies that support their efficacy. We then review… CONTINUE READING