Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer.

  title={Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer.},
  author={Andrew T. Chan and Edward L. Giovannucci and Jeffrey A. Meyerhardt and Eva S. Schernhammer and Gary C. Curhan and Charles S. Fuchs},
  volume={294 8},
CONTEXT Randomized trials of short-term aspirin use for prevention of recurrent colorectal adenoma have provided compelling evidence of a causal relationship between aspirin and colorectal neoplasia. However, data on long-term risk of colorectal cancer according to dose, timing, or duration of therapy with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) remain limited. OBJECTIVE To examine the influence of aspirin and NSAIDs in prevention of colorectal cancer. DESIGN… CONTINUE READING
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