Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis

@article{Wade2006LongtermUO,
  title={Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis},
  author={Derick T. Wade and Petra Makela and Heather House and Cynthia Bateman and Philip J. Robson},
  journal={Multiple Sclerosis},
  year={2006},
  volume={12},
  pages={639 - 645}
}
The object of this study was to monitor the safety and efficacy of long-term use of an oromucosal cannabis-based medicine (CBM) in patients with multiple sclerosis (MS). A total of 137 MS patients with symptoms not controlled satisfactorily using standard drugs entered this open-label trial following a 10-week, placebo-controlled study. Patients were assessed every eight weeks using visual analogue scales and diary scores of main symptoms, and were followed for an average of 434 days (range: 21… 

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