Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis

  title={Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis},
  author={D. Wade and P. Makela and H. House and C. Bateman and P. Robson},
  journal={Multiple Sclerosis},
  pages={639 - 645}
The object of this study was to monitor the safety and efficacy of long-term use of an oromucosal cannabis-based medicine (CBM) in patients with multiple sclerosis (MS). A total of 137 MS patients with symptoms not controlled satisfactorily using standard drugs entered this open-label trial following a 10-week, placebo-controlled study. Patients were assessed every eight weeks using visual analogue scales and diary scores of main symptoms, and were followed for an average of 434 days (range: 21… Expand
248 Citations

Paper Mentions

Interventional Clinical Trial
An extension study to evaluate the long-term safety, tolerability and efficacy of GW-1000-02 treatment in multiple sclerosis.  
ConditionsMultiple Sclerosis, Spasticity
New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids
  • P. F. Smith
  • Medicine
  • Therapeutics and clinical risk management
  • 2010
  • 19
  • PDF
Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis
  • 14
  • Highly Influenced
Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS).
  • 123
  • PDF
Cannabis use in Spanish patients with multiple sclerosis: Fulfilment of patients' expectations?
  • 18
A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine
  • W. Notcutt
  • Medicine
  • Primary Health Care Research & Development
  • 2012
  • 19
  • PDF
Psychopathological and Cognitive Effects of Therapeutic Cannabinoids in Multiple Sclerosis: A Double-Blind, Placebo Controlled, Crossover Study
  • 67
  • PDF
Evaluation of the tolerability and efficacy of Sativex in multiple sclerosis
  • 12
  • Highly Influenced
Cannabis and Multiple Sclerosis.
  • 2
Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review
  • 74
  • PDF


Psychiatric effects of cannabis
  • A. Johns
  • Medicine, Psychology
  • British Journal of Psychiatry
  • 2001
  • 411
  • PDF