Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats.

@article{Peterson2007LongtermTW,
  title={Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats.},
  author={Stephen J Peterson and Daniel Husney and Adam L. Kruger and Rafał Olszanecki and Francesca Ricci and Luigi Fabrizio Rodella and Alessandra Stacchiotti and Rita Rezzani and John Arthur McClung and Wilbert S Aronow and Susumu Ikehara and Nader G Abraham},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={322 2},
  pages={514-20}
}
Apolipoprotein A1 mimetic peptide (D-4F), synthesized from D-amino acid, enhances the ability of high-density lipoprotein to protect low-density lipoprotein (LDL) against oxidation in atherosclerotic disease. Using a rat model of type I diabetes, we investigated whether chronic use of D-4F would lead to up-regulation of heme oxygenase (HO)-1, endothelial cell marker (CD31(+)), and thrombomodulin (TM) expression and increase the number of endothelial progenitor cells (EPCs). Sprague-Dawley rats… CONTINUE READING
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Antioxidant therapy in diabetic complications: what is new

  • R Da Ros, R Assaloni, A Ceriello
  • Curr Vasc Pharmacol
  • 2004
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