Long-term treatment with sulindac in familial adenomatous polyposis: a prospective cohort study.

@article{CruzCorrea2001LongtermTW,
  title={Long-term treatment with sulindac in familial adenomatous polyposis: a prospective cohort study.},
  author={Marcia Cruz-Correa and Linda M. Hylind and Katherine E Romans and Susan V. Booker and Francis M. Giardiello},
  journal={Gastroenterology},
  year={2001},
  volume={122 3},
  pages={
          641-5
        }
}
BACKGROUND & AIMS Management of patients with familial adenomatous polyposis (FAP) can consist of colectomy with ileorectal anastomosis (IRA). Sulindac, a nonsteroidal anti-inflammatory drug, causes regression of colorectal adenomas in the retained rectal segment of FAP patients, although long-term use of this therapy has not been studied. We evaluated the long-term effectiveness and toxicity of sulindac in attempting to maintain retained rectal segments free of adenomas. METHODS Twelve FAP… CONTINUE READING
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