Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus.

@article{Nomura2005LongtermTW,
  title={Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus.},
  author={Shosaku Nomura and Akira Shouzu and Seitarou Omoto and Mitsushige Nishikawa and Toshiji Iwasaka},
  journal={Thrombosis research},
  year={2005},
  volume={115 4},
  pages={277-85}
}
In type 2 diabetes mellitus, there is increased risk of nephropathy and cardiovascular complications and the incidence of renal failure increases in advanced stages of the disease. Nifedipine, a dihydropyridine-type calcium antagonist, improves endothelial function in hypercholesterolemia by enhancing nitric oxide function, and increases endothelial nitric oxide bioavailability by antioxidative mechanisms. We administered nifedipine, 50 mg/day, to the hypertensive patients for 12 months. There… CONTINUE READING

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