Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase.

@article{Yoshikawa2008LongtermTW,
  title={Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase.},
  author={M. Yoshikawa and T. Shinomiya and Naoko Takayasu and H. Tsukamoto and M. Kawaguchi and Hiroyuki Kobayashi and T. Oka and A. Hashimoto},
  journal={Journal of pharmacological sciences},
  year={2008},
  volume={107 3},
  pages={
          270-6
        }
}
Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor-related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine augments the gene expression of serine racemase and DAO in rat brain. To further elucidate the mechanism underlying the activation of NMDA receptors following chronic opioid administration, we have evaluated the effects of the chronic… Expand
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TLDR
The present findings indicate that increasing the serine racemase mRNA and no changes in the DAO mRNA after the chronic administration could contribute to the elevation of the d-serine level in the forebrain, and that serine Racemase and DAO could play an important role in the regulation of N-methyl-d-aspartate receptors via the d -serine metabolism. Expand
Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.
TLDR
The present results are the first to suggest an interaction between the expression of the mRNAs for the D-serine-related enzymes and the opioid receptor activation. Expand
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The altered expressions of NMDA receptor subunits, especially in NAcc, of morphine‐dependent rats may represent a neuroadaptation to chronic morphine and suggest a mechanism for the changes of glutamatergic transmission found in the extended amygdala in dependent rats. Expand
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