Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.

@article{Abe2004LongtermTW,
  title={Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.},
  author={Kohtaro Abe and Hiroaki Shimokawa and Keiko Morikawa and Toyokazu Uwatoku and Keiji Oi and Yasuharu Matsumoto and Tsuyoshi Hattori and Yutaka Nakashima and Kozo Kaibuchi and Katsuo Sueishi and Akira Takeshit},
  journal={Circulation research},
  year={2004},
  volume={94 3},
  pages={385-93}
}
Primary pulmonary hypertension is a fatal disease characterized by endothelial dysfunction, hypercontraction and proliferation of vascular smooth muscle cells (VSMCs), and migration of inflammatory cells, for which no satisfactory treatment has yet been developed. We have recently demonstrated that intracellular signaling pathway mediated by Rho-kinase, an effector of the small GTPase Rho, is involved in the pathogenesis of arteriosclerosis. In the present study, we examined whether the Rho… CONTINUE READING
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