Long-term treatment ofhumanimmunodeficiency virus-infected cells withantisense oligonucleotide phosphorothioates

@inproceedings{Lisziewicz1993LongtermTO,
  title={Long-term treatment ofhumanimmunodeficiency virus-infected cells withantisense oligonucleotide phosphorothioates},
  author={Julianna Lisziewicz and And Sudhiragrawal},
  year={1993}
}
Theantiviral activity ofantisense oligodeoxy- nucleotide phosphorothioates complementary tothetatgene, thegagmRNA,andtherevmRNA werestudied inalong-term infection model. Threeantisense oligonucleotides directed to thesplice-acceptor site ofthetat genefailed tosuppress human immunodeficiency virus type 1replication at1,M concentra- tion inlong-term culture. Incontrast, twooligodeoxynucleotide phosphorothioates (28-mer) complementary tothegagandthe revmRNAsinhibited viral replication for>80days… CONTINUE READING