Long-term treatment of spontaneously hypertensive rats with losartan and electrophysiological remodeling of cardiac myocytes.

@article{Cerbai2000LongtermTO,
  title={Long-term treatment of spontaneously hypertensive rats with losartan and electrophysiological remodeling of cardiac myocytes.},
  author={Elisabetta Cerbai and Antonio S Crucitti and Laura Sartiani and Petra De Paoli and Roberto Pino and Mar{\'i}a Luisa Rodr{\'i}guez and Gian Franco Gensini and Alessandro Mugelli},
  journal={Cardiovascular research},
  year={2000},
  volume={45 2},
  pages={388-96}
}
OBJECTIVE Cardiac hypertrophy due to pressure overload is associated with several cellular electrophysiological alterations such as prolongation of action potential duration (APD), decrease in transient outward current (Ito) and occurrence of the pacemaker current I(f). These alterations may play a role in sudden arrhythmic death, which is a major risk factor in myocardial hypertrophy and failure. Since angiotensin II is a key signal for myocyte hypertrophy, we tested if an 8-week treatment of… CONTINUE READING

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In vivo blockade

  • E Cerbai, A Crucitti, ML Rodriguez
  • Cardiovascular Research
  • 2000

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