Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats

@article{Ma2009LongtermTO,
  title={Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats},
  author={Shiping Ma and Shaofeng Xu and Bin Liu and Jiang Li and Nan Feng and Ling Wang and Xiaoliang Wang},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2009},
  volume={379},
  pages={565-574}
}
It is shown that l-3-n-butylphthalide (l-NBP), the isomer of dl-NBP (racemic 3-n-butylphthalide, a new anti-cerebral ischemic agent) significantly attenuated cerebral hypoperfusion-induced learning dysfunction and brain damage in rats. In the present study, l-NBP (10 and 30 mg/kg) long-term (3-month) treatment of aged rat (21-month-old) significantly improved the learning and memory capability measured by the Morris water maze test. Hematoxylin–eosin-stained slices showed that both l-NBP at 30… CONTINUE READING

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