Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats

  title={Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats},
  author={Shiping Ma and Shaofeng Xu and Bin Liu and Jiang Li and Nan Feng and Ling Wang and Xiaoliang Wang},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
It is shown that l-3-n-butylphthalide (l-NBP), the isomer of dl-NBP (racemic 3-n-butylphthalide, a new anti-cerebral ischemic agent) significantly attenuated cerebral hypoperfusion-induced learning dysfunction and brain damage in rats. In the present study, l-NBP (10 and 30 mg/kg) long-term (3-month) treatment of aged rat (21-month-old) significantly improved the learning and memory capability measured by the Morris water maze test. Hematoxylin–eosin-stained slices showed that both l-NBP at 30… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 13 extracted citations


Publications referenced by this paper.
Showing 1-10 of 44 references

l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats.

The Journal of pharmacology and experimental therapeutics • 2007
View 6 Excerpts

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 1 Excerpt

Low doses of memantine disrupt memory in adult rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…