Long-term treatment of clarithromycin at a low concentration improves hydrogen peroxide-induced oxidant/antioxidant imbalance in human small airway epithelial cells by increasing Nrf2 mRNA expression

@inproceedings{Iwayama2017LongtermTO,
  title={Long-term treatment of clarithromycin at a low concentration improves hydrogen peroxide-induced oxidant/antioxidant imbalance in human small airway epithelial cells by increasing Nrf2 mRNA expression},
  author={Kuninori Iwayama and Ayuko Kusakabe and Keisuke Ohtsu and Takahiro Nawano and Ryosuke Tatsunami and Ko-ichi Ohtaki and Yoshiko Tampo and Nobumasa Hayase},
  booktitle={BMC Pharmacology and Toxicology},
  year={2017}
}
BackgroundClarithromycin (CAM), a representative macrolide antibiotic, has been used widely at low doses for long-term therapy of chronic inflammatory airway diseases. Anti-inflammatory effects of macrolide antibiotics were first discovered in clinical practice. Although oxidative stress is known as a key pathogenesis factor in chronic airway inflammatory diseases, the mechanism of action of low-dose, long-term CAM therapy remains unclear. We aimed to examine the cytoprotective action of CAM… CONTINUE READING
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