Long-term toxicology effects of prednimustine in comparison with chlorambucil, prednisolone, and chlorambucil plus prednisolone in Sprague-Dawley rats.

Abstract

Chlorambucil was linked to prednisolone to improve the therapeutic and toxic properties of this potent alkylating agent, which is known to induce second tumors in humans. To compare the carcinogenic potency of the linked compound with that of the respective individual agents and of their unlinked mixture, prednimustine (I), chlorambucil (II), prednisolone… (More)

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@article{Berger1986LongtermTE, title={Long-term toxicology effects of prednimustine in comparison with chlorambucil, prednisolone, and chlorambucil plus prednisolone in Sprague-Dawley rats.}, author={Martin R. Berger and Maximilian Habs and Dietrich Schm{\"a}hl}, journal={Seminars in oncology}, year={1986}, volume={13 1 Suppl 1}, pages={8-13} }