Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates.

  title={Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates.},
  author={Sh{\^o}z{\^o} Takayama and A. G. C. Renwick and Sonny L. Johansson and Unnur P. Thorgeirsson and Masahiro Tsutsumi and Dan W. Dalgard and Susan M. Sieber},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={53 1},
Twenty-one monkeys (cynomolgus, rhesus, African green) were fed cyclamate (100 mg/kg and 500 mg/kg) in the diet five times per week from a few days after birth and continuing for up to 24 years. Malignant tumors were diagnosed in three 24-year-old cyclamate monkeys; these were metastatic colon carcinoma (rhesus; 500 mg/kg), metastatic hepatocellular carcinoma (cynomolgus; 500 mg/kg), and a small, well differentiated adenocarcinoma of the prostate (cynomolgus; 100 mg/kg). Benign tumors were… 

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