Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene-diisocyanate (80/20) in rats and mice.

@article{Loeser1983LongtermTA,
  title={Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene-diisocyanate (80/20) in rats and mice.},
  author={Eva Loeser},
  journal={Toxicology letters},
  year={1983},
  volume={15 1},
  pages={71-81}
}
Groups of male and female rats and mice were exposed to 0.05 and 0.15 ppm of toluene-diisocyanate (TDI) by inhalation for 6 h/day, 5 days/week for approx. 2 years. Type and incidence of tumours and the number of tumour-bearing animals of either species did not indicate any carcinogenic effect. Haematology, biochemistry, urinalysis, and cytogenicity did not reveal any untoward effect. Increased mortality (females only), reduced weight gain and signs of irritation in the upper and lower… CONTINUE READING