Long-term survival of transplanted basal forebrain cells following in vitro propagation with fibroblast growth factor-2.

@article{Minger1996LongtermSO,
  title={Long-term survival of transplanted basal forebrain cells following in vitro propagation with fibroblast growth factor-2.},
  author={Stephen L. Minger and L. J. Fisher and Jasodhara Ray and Fred H. Gage},
  journal={Experimental neurology},
  year={1996},
  volume={141 1},
  pages={12-24}
}
The intracerebral transplantation of freshly dissected fetal tissue containing cholinergic neurons of the developing basal forebrain has been reported to reverse lesion-induced or age-related cognitive deficits in animal models of cholinergic neuronal degeneration. Grafts of cultured fetal neurons, however, have generally shown poor cellular survival and limited therapeutic benefit. We tested the hypothesis that recent advances in the identification of growth factors that promote the survival… CONTINUE READING

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