Long-term supplementation with a high cholesterol diet decreases the release of ATP from the caudal artery in aged rats.

@article{Hashimoto1998LongtermSW,
  title={Long-term supplementation with a high cholesterol diet decreases the release of ATP from the caudal artery in aged rats.},
  author={Michio Hashimoto and Kazumasa Shinozuka and Yoko Tanabe and Hossain Md Shahdat and Shuji Gamoh and Young Mi Kwon and Yoshio Tanaka and Masaru Kunitomo and Sumio Masumura},
  journal={Life sciences},
  year={1998},
  volume={63 21},
  pages={1879-85}
}
We examined the effects of high cholesterol (HC) diet on the spontaneous and noradrenaline-induced release of ATP, ADP, AMP and adenosine from caudal arteries and on the plasma levels of these adenyl purines in aged (100-week-old) Wistar rats. Administration of this diet for 12 weeks significantly reduced spontaneous and noradrenaline (1 micromol/L)-evoked release of adenyl purines from the caudal arteries relative to rats given the control diet The unsaturation index of fatty acids (UI), which… CONTINUE READING