Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: neuroprotection of dopaminergic neurons.

@article{Maesawa2004LongtermSO,
  title={Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: neuroprotection of dopaminergic neurons.},
  author={Satoshi Maesawa and Yoshiki Kaneoke and Yasukazu Kajita and Naotaka Usui and Nobuaki Misawa and Atsuo Nakayama and Jun Yoshida},
  journal={Journal of neurosurgery},
  year={2004},
  volume={100 4},
  pages={679-87}
}
OBJECT The goal of this study was to evaluate the neuroprotective effects conferred by long-term electrical stimulation of the subthalamic nucleus (STN) against degeneration of dopaminergic neurons by assessing motor functional and immunohistological findings in hemiparkinsonian rats. METHODS In 13 of 25 rats, a concentric microelectrode was stereotactically implanted into the right STN under the guidance of extracellular microelectrode recording. After this had been done the animals were… CONTINUE READING
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