Long-term safety of tacrolimus ointment in atopic dermatitis.

  title={Long-term safety of tacrolimus ointment in atopic dermatitis.},
  author={Anita Remitz and Sakari Reitamo},
  journal={Expert opinion on drug safety},
  volume={8 4},
BACKGROUND Tacrolimus ointment has shown efficacy as monotherapy in both short- and long-term studies in atopic dermatitis. Absorption of tacrolimus after topical application is dependent on the barrier function of the skin. Absorption through the intact epidermis is very low and eczematic skin a little higher. In comparison to systemic tacrolimus used for prevention and treatment of rejection after organ transplantation, the bioavailability of topical tacrolimus in patients with atopic… CONTINUE READING
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