Long-term retention of ECM hydrogel after implantation into a sub-acute stroke cavity reduces lesion volume.

@article{Ghuman2017LongtermRO,
  title={Long-term retention of ECM hydrogel after implantation into a sub-acute stroke cavity reduces lesion volume.},
  author={Harmanvir Ghuman and Madeline Gerwig and Francesca J. Nicholls and Jessie R. Liu and Julia Donnelly and Stephen F. Badylak and Michel Modo},
  journal={Acta biomaterialia},
  year={2017},
  volume={63},
  pages={
          50-63
        }
}
Salvaging or functional replacement of damaged tissue caused by stroke in the brain remains a major therapeutic challenge. In situ gelation and retention of a hydrogel bioscaffold composed of 8mg/mL extracellular matrix (ECM) can induce a robust invasion of cells within 24h and potentially promote a structural remodeling to replace lost tissue. Herein, we… CONTINUE READING