Long-term responses of women to indole-3-carbinol or a high fiber diet.

  title={Long-term responses of women to indole-3-carbinol or a high fiber diet.},
  author={H. Leon Bradlow and Jon J. Michnovicz and Michael Halper and Douglas George Miller and George Y. C. Wong and Michael P. Osborne},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={3 7},
We test the hypothesis that the estrogen metabolite ratio 2-OH-estrone:estriol can be raised via dietary indole-3-carbinol (I3C) and that this higher ratio can be sustained over a 3-month test period. We also explore the possible role of pure fiber on estradiol metabolism. Using a randomized clinical trial with three arms, each containing 20 subjects, arm 1 received 400 mg/day of I3C daily for 3 months, arm 2 received 20 g of alpha-cellulose daily for the same time period as a source of added… CONTINUE READING


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