Long-term responses of women to indole-3-carbinol or a high fiber diet.

@article{Bradlow1994LongtermRO,
  title={Long-term responses of women to indole-3-carbinol or a high fiber diet.},
  author={H. Leon Bradlow and Jon J. Michnovicz and Michael Halper and Douglas George Miller and George Y. C. Wong and Michael P. Osborne},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1994},
  volume={3 7},
  pages={
          591-5
        }
}
We test the hypothesis that the estrogen metabolite ratio 2-OH-estrone:estriol can be raised via dietary indole-3-carbinol (I3C) and that this higher ratio can be sustained over a 3-month test period. We also explore the possible role of pure fiber on estradiol metabolism. Using a randomized clinical trial with three arms, each containing 20 subjects, arm 1 received 400 mg/day of I3C daily for 3 months, arm 2 received 20 g of alpha-cellulose daily for the same time period as a source of added… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 20 REFERENCES

The Effect of cruciferous vegetable consumption on colon cancer incidence

  • L. Kohlmeyer, R. Dortchy
  • Int. J. Epidemiol., in press,
  • 1994

Estradiob 1 6 a - hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus : a possible model for the hormonal etiology of breast cancer in humans

  • H. L. Bradbow, R. J. Hershcopf, C. P. Martucci, J. Fishman
  • Proc . NatI . Acad . Sci . USA
  • 1992

Effect of dietary indobe-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice

  • H. L. Bradbow, J. J. Michnovicz, N. T. Tebang, M. P. Osborne
  • Carcinogenesis (Lond.),
  • 1991

Induction of human breast cancer cells by 2 , 3 , 7 , 8 - tetrachborodibenzo - P - dioxin

  • J. F. Gierthy, D. W. Lincoln, +4 authors G. E. Swaneck
  • Biochem . Biophys . Res . Commun .
  • 1989

led.), Adipose Tissue and Reproduction

  • R. Frisch
  • 1989

Similar Papers

Loading similar papers…