Long-term responses of the mouse uterus to neonatal diethylstilbestrol treatment and to later sex hormone exposure.

@article{Ostrander1985LongtermRO,
  title={Long-term responses of the mouse uterus to neonatal diethylstilbestrol treatment and to later sex hormone exposure.},
  author={Patricia L. Ostrander and Kimberly Tracey Mills and Howard Alan Bern},
  journal={Journal of the National Cancer Institute},
  year={1985},
  volume={74 1},
  pages={
          121-35
        }
}
The effects of ovariectomy at 1 month of age and continuous 17 beta-estradiol (E2) and/or progesterone (P) replacement on the uterus of BALB/cCrgl mice neonatally treated with diethylstilbestrol [(DES) CAS: 56-53-1; alpha-alpha'-diethyl-4,4'-stilbenediol] or sesame oil were recorded after 1, 4, 7, and 10 months of treatment. DES-exposed uteri were found to be hypoplastic, less responsive to the growth-promoting effects of E2, and more likely to develop smooth muscle abnormalities after… CONTINUE READING
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