Long-term regulation of signalling components of adenylyl cyclase and mitogen-activated protein kinase in the pre-frontal cortex of human opiate addicts.

Abstract

Opiate addiction involves the development of chronic adaptive changes in micro -opioid receptors and associated pathways (e.g. cAMP signalling) which lead to neuronal plasticity in the brain. This study assessed the status of cAMP and mitogen-activated protein kinase (MAPK) pathways in brains (pre-frontal cortex) of chronic opiate addicts. In these subjects… (More)

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@article{FerrerAlcn2004LongtermRO, title={Long-term regulation of signalling components of adenylyl cyclase and mitogen-activated protein kinase in the pre-frontal cortex of human opiate addicts.}, author={Marcelino Ferrer-Alc{\'o}n and Mar{\'i}a-Julia Garc{\'i}a-Fuster and Romano La Harpe and Jes{\'u}s Andr{\'e}s Garc{\'i}a-Sevilla}, journal={Journal of neurochemistry}, year={2004}, volume={90 1}, pages={220-30} }