Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia.

@article{Levenson2000LongtermRO,
  title={Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia.},
  author={Jonathan M. Levenson and Shogo Endo and Lorna S. Kategaya and Raymond I Fernandez and D G Brabham and Jeannie Chin and John H. Byrne and Arnold Eskin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 23},
  pages={12858-63}
}
An increase in transmitter release accompanying long-term sensitization and facilitation occurs at the glutamatergic sensorimotor synapse of Aplysia. We report that a long-term increase in neuronal Glu uptake also accompanies long-term sensitization. Synaptosomes from pleural-pedal ganglia exhibited sodium-dependent, high-affinity Glu transport. Different treatments that induce long-term enhancement of the siphon-withdrawal reflex, or long-term synaptic facilitation increased Glu uptake… CONTINUE READING

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Nature (London) 403, 316–321

D. J. Rossi, T. Oshima, D. Attwell
Levenson et al. PNAS u November • 2000

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