Long-term regulation of locus ceruleus sensitivity to corticotropin-releasing factor by swim stress.

@article{Curtis1999LongtermRO,
  title={Long-term regulation of locus ceruleus sensitivity to corticotropin-releasing factor by swim stress.},
  author={Andre L. Curtis and L A Pavcovich and Rita J Valentino},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={289 3},
  pages={1211-9}
}
Corticotropin-releasing factor (CRF) acts as a putative neurotransmitter in the locus ceruleus (LC) to mediate its activation by certain stressors. In this study, we quantified LC sensitivity to CRF 24 h after swim stress, at a time when behavioral depression that is sensitive to antidepressants is apparent. Rats were placed in a tank with 30 cm (swim stress) or 4 cm water and 24 h later, either behavior was monitored in a forced swim test or LC discharge was recorded. Swim stress rats were… CONTINUE READING