Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats.

@article{Faivre2004LongtermRR,
  title={Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats.},
  author={Jamila Faivre and J{\^e}rome Clerc and Ren{\'e} G{\'e}rolami and Julie Herv{\'e} and Mich{\`e}le Longuet and Bingkai Liu and J. Roux and Fr{\'e}d{\'e}ric Moal and M. Perricaudet and Christian Br{\'e}chot},
  journal={Cancer research},
  year={2004},
  volume={64 21},
  pages={
          8045-51
        }
}
Radioiodine therapy of nonthyroid cancers after sodium iodide symporter (NIS) gene delivery has been proposed as a potential application of gene therapy. However, it seems to be precluded by the rapid efflux of taken up iodine from most transduced xenografted tumors. We present an in vivo kinetic study of NIS-related hepatic iodine uptake in an aggressive model of hepatocarcinoma induced by diethylnitrosamine in immunocompetent Wistar rats. We followed the whole-body iodine distribution by… CONTINUE READING
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