Long-term proton pump inhibitor use is associated with vascular calcification in chronic kidney disease: a cross-sectional study using propensity score analysis.

@article{Fusaro2013LongtermPP,
  title={Long-term proton pump inhibitor use is associated with vascular calcification in chronic kidney disease: a cross-sectional study using propensity score analysis.},
  author={Maria Cl{\'a}udia G. Oliveira Fusaro and Marianna Noale and Giovanni Tripepi and Sandro Giannini and Angela D'Angelo and Angelo Pica and Lorenzo A Cal{\`o} and Davide Miozzo and Maurizio Gallieni},
  journal={Drug safety},
  year={2013},
  volume={36 8},
  pages={635-42}
}
BACKGROUND Proton pump inhibitors (PPIs) are a class of drugs that is extensively used for common gastrointestinal disorders and often prescribed long-term for years. Long-term PPI treatment is associated with an increased risk of fractures in the general population. Several studies have suggested a relationship between vascular calcification, which is a predictor of cardiovascular morbidity and mortality, impaired bone metabolism and fractures. In dialysis patients, vascular calcifications are… CONTINUE READING
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