Long-term proliferation of mouse primordial germ cells in culture

  title={Long-term proliferation of mouse primordial germ cells in culture},
  author={James L. Resnick and Lynn S. Bixler and Linzhao Cheng and Peter J Donovan},
PRIMORDIAL germ cells (PGCs) are first identifiable as a population of about eight alkaline phosphatase-positive cells in the 7.0 days postcoitum mouse embryo1. During the next 6 days of development they proliferate to give rise to the 25,000 cells that will establish the meiotic population2. Steel factor is required for PGC survival both in vivo3 and in vitro4,5 and together with leukaemia inhibitory factor stimulates PGC proliferation in vitro6. In feeder-dependent culture, PGCs will… CONTINUE READING
Highly Influential
This paper has highly influenced 35 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 280 extracted citations

Similar Papers

Loading similar papers…