Long-term prevention of premature coronary atherosclerosis in homozygous familial hypercholesterolemia.

@article{Jaeger2002LongtermPO,
  title={Long-term prevention of premature coronary atherosclerosis in homozygous familial hypercholesterolemia.},
  author={Beate Roxane Jaeger and Theoharis Tsobanelis and Frank M. Bengel and Markus Schwaiger and Dietrich Seidel},
  journal={The Journal of pediatrics},
  year={2002},
  volume={141 1},
  pages={125-8}
}
Homozygous familial hypercholesterolemia (FHH) leads to severe premature atherosclerosis. A 22-year-old woman with FHH has been treated with a combination of H.E.L.P. apheresis (heparin-mediated extracorporeal LDL precipitation) and statins for 15 years. The combined treatment maintained a plasma LDL-cholesterol reduction from baseline of 840 to 122 mg/dL (85% reduction). In addition, H.E.L.P. apheresis reduced the elevated lipoprotein(a) and fibrinogen levels by 60% to 70%. All xanthomata… CONTINUE READING