Long-term potentiation requires activation of calcium-independent phospholipase A2.

  title={Long-term potentiation requires activation of calcium-independent phospholipase A2.},
  author={Matthew J. Wolf and Yuichi Izumi and Charles F Zorumski and Richard W. Gross},
  journal={FEBS letters},
  volume={377 3},
The predominant phospholipase activity present in rat hippocampus is a calcium-independent phospholipase A2 (302.9 +/- 19.8 pmol/mg.min for calcium-independent phospholipase A2 activity vs. 14.6 +/- 1.0 pmol/mg.min for calcium-dependent phospholipase A2 activity). This calcium-independent phospholipase A2 is exquisitely sensitive to inhibition by the mechanism-based inhibitor, (E)-6-(bromomethylene)-tetrahydro-3-(1-naphthalenyl)-2H-pyran -2-one (BEL). Moreover, treatment of hippocampal slices… CONTINUE READING
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