Long-term potentiation of the responses to parallel fiber stimulation in mouse cerebellar cortex in vivo

@article{Wang2009LongtermPO,
  title={Long-term potentiation of the responses to parallel fiber stimulation in mouse cerebellar cortex in vivo},
  author={Xinming Wang and Guangping Chen and Wangcai Gao and Timothy J. Ebner},
  journal={Neuroscience},
  year={2009},
  volume={162},
  pages={713-722}
}
Long-term potentiation (LTP) of parallel fiber-Purkinje cell (PF-PC) synapses in the cerebellum has been suggested to underlie aspects of motor learning. Previous in vitro studies have primarily used low frequency PF stimulation conditioning paradigms to generate either presynaptic PF-PC LTP (4-8 Hz) or postsynaptic PF-PC LTP (1 Hz). Little is known about the conditions that evoke PF-PC LTP in vivo. High frequency stimulation in vivo increases PC responsiveness to peripheral stimuli; however… CONTINUE READING
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