Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus

  title={Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus},
  author={Robert M. Douglas and Graham V. Goddard},
  journal={Brain Research},
When the entorhinal cortex is electrically stimulated, a monosynaptic evoked potential is produced in the ipsilateral hippocampus. Twenty-four hours after a 120-pulse stimulation train, the response to a single test pulse was found to be increased. Stimulation trains presented at a rate of 1/day had a cumulative effect on both the population EPSP and spike components of the evoked potential, and the potentiation so produced lasted at least 12 days. In a few cases, retested 2 months after the… Expand
Evoked potentials and long-term potentiation in the mouse dentate gyrus after stimulation of the entorhinal cortex
Long-term potentiation was demonstrated in both pathways after administration of tetanic stimuli of various parameters, consistent with the different sites of termination of the two paths. Expand
Long-term potentiation facilitates behavioral responding to single-pulse stimulation of the perforant path.
The results document a clear link between increases in synaptic efficacy and changes in behavior and demonstrate the ability of LTP to serve as at least one component of the neural bases of learning and memory. Expand
Heterosynaptic postactivation potentiation in hippocampal CA 3 neurons: Long-term changes of the postsynaptic potentials
The heterosynaptic mode of the potentiation as well as the changes of the IPSPs indicate that not only the excitatory pathway but also the inhibitory pathway must be considered in explaining postactivation potentiation in this hippocampal field. Expand
Low frequency perforant path stimulation as a conditioned stimulus demonstrates correlations between long-term synaptic potentiation and learning
The observed correlation of LTP in the conditioning pathway with the learning ability suggests an involvement ofLTP at least in the acquisition and early retention of this learned behavior, but the results do not finally clarify the role of L TP in long-term retention. Expand
Inhibitory modulation of long-term potentiation: Evidence for a postsynaptic locus of control
The results support Marr's proposal that local inhibitory networks may set the threshold for producing long-term synaptic modification and do not support Hebb's nor Uttley's proposal since the long- term synaptic modification did not depend on either the occurrence or the absence of a postsynaptic action potential. Expand
Kindling with stimulation of the dentate gyrus. II. Effects on evoked field potentials
The results suggest that kindling stimulation may potentiate responsiveness of the directly activated dentate granule cells to inputs from the PP, but at the same time suppress the output of thegranule cells resulting from this input. Expand
Absence of long-term potentiation in the subcortically deafferented dentate gyrus
These findings suggest that either (1) coactivation of entorhinal and subcortical inputs is essential for the induction of long-lasting plastic changes in the dentate gyrus, or (2) the long-term potentiation mechanism is saturated by the chronically occurring interictal discharges in the sub cortically denervated dentate Gyrus. Expand
Field potential evidence for long-term potentiation of feed-forward inhibition in the rat dentate gyrus
Perforant path/granule cell LTP is normally accompanied by long-term potentiation of a feed-forward inhibitory pathway which may involve interneurones, and picrotoxin blocked the decrease in slope of the E-S relationship which normally accompanies LTP. Expand
A study of synaptic plasticity in hippocampal slices.
The results suggest that monosynaptic EPSPs can undergo long-lasting (up to 30 min) post-tetanic potentiation. Expand
Calcium-induced long-term potentiation in the hippocampus
Brief exposure of in vitro hippocampal slices to a high extracellular calcium concentration results in a long-term increase in synaptic efficacy which is similar in many respects to long- term potentiation induced by tetanic stimulation of hippocampal excitatory afferents. Expand


Entorhinal activation of dentate granule cells.
In rabbits, anesthetized with urethane-chloralose, the activation of the granule cells of the dentate area by perforant path fibres from the entorhinal area was studied by intracellular and extracellular recording and the efficiency of the perforan path excitatory synapses was greatly increased by raising the rate of stimulation. Expand
A permanent change in brain function resulting from daily electrical stimulation.
High-intensity stimulation studies revealed that the development of convulsions was not based simply on threshold reduction, but involved complex reorganization of function. Expand
  • D. P. Lloyd
  • Psychology, Medicine
  • The Journal of general physiology
  • 1949
Following tetanic afferent stimulation of a monosynaptic reflex pathway, the transmission through that pathway of isolated reflex volleys is enhanced for some minutes, and afferent impulses are increased following a tetanus, and in a fashion that parallels the course of monosYNaptic reflex potentiation. Expand
The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region. Expand
Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
1. The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbitsExpand
Origin and termination of the hippocampal perforant path in the rat studied by silver impregnation
A detailed study of the origin and termination of the so‐called perforant path of the hippocampal region has been made in the rat, finding the origin to be in the medial part of the entorhinal area, from the most dorsal to the most ventral levels. Expand
Projection of the lateral part of the entorhinal area to the hippocampus and fascia dentata
A third group of perforant fibers, bing intermediate to the others with regard to both origin and termination has been noticed in one animal. Expand
Autoradiographic studies of the commissural and ipsilateral association connections of the hippocampus and dentate gyrus. I. The commissural connections
The commissural connections of the two major cytoarchitectonic fields of the hippocampus (fields CA1 and CA3) and of the dentate gyrus of the rat have been studied autoradiographically followingExpand
Ipsilateral afferents to the commissural zone of the fascia dentata, demonstrated in decommissurated rats by silver impregnation
  • J. Zimmer
  • Biology, Medicine
  • The Journal of comparative neurology
  • 1971
An ipsilateral pathway to the commissural zone of the dentate fascia has been demonstrated in the rat using the Fink‐Heimer silver impregnation method and the resulting degeneration was shown to be of purely ipsilaterally origin. Expand