Long-term potentiation of polysynaptic responses in layer V of the sensorimotor cortex induced by theta-patterned tetanization in the awake rat.

@article{Werk2003LongtermPO,
  title={Long-term potentiation of polysynaptic responses in layer V of the sensorimotor cortex induced by theta-patterned tetanization in the awake rat.},
  author={Christine M. Werk and C. A. Chapman},
  journal={Cerebral cortex},
  year={2003},
  volume={13 5},
  pages={500-7}
}
Although the neocortex in awake, adult animals is resistant to the induction of long-term potentiation (LTP), synaptic potentiation may be enhanced by rhythmic patterns of activation that evoke short- term synaptic facilitation effects. The effectiveness of stimulation patterned after the theta (4-12 Hz) EEG rhythm for the induction of LTP of sensorimotor cortex responses to corpus callosum stimulation was assessed in vivo by inducing LTP using either high- frequency (300 Hz) trains or paired… CONTINUE READING
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