Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists

@article{Harris1986LongtermPO,
  title={Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists},
  author={E. W. Harris and C. Cotman},
  journal={Neuroscience Letters},
  year={1986},
  volume={70},
  pages={132-137}
}
  • E. W. Harris, C. Cotman
  • Published 1986
  • Biology, Medicine
  • Neuroscience Letters
  • Receptors preferentially activated by the excitatory amino acid N-methyl-D-aspartate (NMDA) do not mediate synaptic transmission in the hippocampus but are involved in initiating long-term potentiation (LTP) in hippocampal region CA1. We have examined the role of NMDA receptors in LTP of the commissural/associational and mossy fiber pathways to region CA3 pyramidal neurons. In the commissural/associational pathway, NMDA receptor blockers did not reduce synaptic responses but reversibly blocked… CONTINUE READING

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