Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate.

@article{Brown2000LongtermPI,
  title={Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate.},
  author={George P Brown and Robert D. Blitzer and John H. Connor and T Wong and Shirish S Shenolikar and Ravi Iyengar and Emmanuel M. Landau},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 21},
  pages={7880-7}
}
Long-term potentiation (LTP) can be induced in the Schaffer collateral-->CA1 synapse of hippocampus by stimulation in the theta frequency range (5-12 Hz), an effect that depends on activation of the cAMP pathway. We investigated the mechanisms of the cAMP contribution to this form of LTP in the rat hippocampal slice preparation. theta pulse stimulation (TPS; 150 stimuli at 10 Hz) by itself did not induce LTP, but the addition of either the beta-adrenergic agonist isoproterenol or the cAMP… CONTINUE READING