Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors.

@article{Harris1984LongtermPI,
  title={Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors.},
  author={E. W. Harris and Alan H Ganong and Carl Cotman},
  journal={Brain research},
  year={1984},
  volume={323 1},
  pages={132-7}
}
A series of omega-phosphono-alpha-carboxylic acids were tested as antagonists of excitatory amino acid depolarizations and long-term potentiation (LTP) in region CA1 of rat hippocampal slices. The 5- and 7-phosphono compounds (+/- AP5 and +/- AP7) blocked N-methyl-D-aspartate (NMDA) depolarizations and prevented the induction of LTP of the synaptic field potential and population spike components of the Schaffer collateral response. +/- AP5 and +/- AP7 did not reduce kainate or quisqualate… CONTINUE READING
128 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 128 extracted citations

Similar Papers

Loading similar papers…