Long-term potentiation in the hippocampus induced by platelet-activating factor.

Abstract

Platelet-activating factor (PAF) is an ether phospholipid that serves as an autacoid in a wide range of biological processes. We found that when PAF was added to hippocampal slices, it induced a stable and concentration-dependent increase in excitatory postsynaptic potential and population spike recordings (long-term potentiation [LTP]). The PAF effect was blocked by the PAF receptor antagonists BN 52021 and WEB 2086 and the N-methyl-D-aspartate receptor antagonists MK 801 and 2-amino-5-phosphonovalerate. However, these PAF receptor antagonists did not block LTP induced by high frequency stimulation. The facilitation induced by PAF could not be reversed by PAF receptor antagonists. Induction of either PAF-or tetanus-triggered facilitation occluded the subsequent expression of the other, suggesting a common pathway. LTP is a type of synaptic plasticity associated with the formation of memory, and PAF may play an important modulatory role in this process.

Statistics

050100'95'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

472 Citations

Semantic Scholar estimates that this publication has 472 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Wieraszko1993LongtermPI, title={Long-term potentiation in the hippocampus induced by platelet-activating factor.}, author={Andrzej Wieraszko and Guan-qiao Li and Elizabeth Kornecki and Macalus V Hogan and Yigal H . Ehrlich}, journal={Neuron}, year={1993}, volume={10 3}, pages={553-7} }