Long-term potentiation in spinal nociceptive systems—how acute pain may become chronic

@article{Rygh2005LongtermPI,
  title={Long-term potentiation in spinal nociceptive systems—how acute pain may become chronic},
  author={Lars J{\o}rgen Rygh and Frode Svendsen and Atle Fisk{\aa} and Fr{\o}ydis Haugan and Arne Tj{\o}lsen},
  journal={Psychoneuroendocrinology},
  year={2005},
  volume={30},
  pages={959-964}
}
Chronic pain is a major problem since it is difficult to treat and the understanding of the underlying neurobiology is sparse. The mechanisms underpinning the transition of acute into chronic pain remain unclear. However, long-term potentiation (LTP) in spinal nociceptive systems may be one such mechanism. Here, we briefly review the literature regarding LTP in spinal nociceptive systems including our own data on LTP in deep convergent nociceptive neurons. Furthermore, we discuss the role of… CONTINUE READING
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